Sunday, October 28, 2007
Saturday, October 27, 2007
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SYNTHESIS AND CHARACTERIZATION OF POTENTIAL ANTITUMOR RUTHENIUM ASCORBATE COMPLEXES
By
ANN MARGARETTE G. AMARGA
March 2002
ABSTRACT
New complexes of ruthenium with biologically relevant ligands such as ascorbate: (C6H7O6)2Ru(C6H6O6)2 (MW = 799.1), Ru2Cl5(C6H7O6)4 (MW = 1081.7), Ru(C6H7O6)2 (MW = 451.0) and RuCl2(C6H6O7)·H2O (MW = 363.9) were synthesized and characterized through Ultraviolet-visible, Mass and Infrared spectroscopy.
Ultraviolet-visible spectroscopy indicates the formation of new complexes through an observed hypsochromic shift of the ligand-to-metal charge transfer band. Mass spectroscopy established the molecular weights of the compounds while the presence of the υ(Ru-O) band at ~800 cm-1 in the IR spectrum of the individual complexes supports coordination of the ascorbate ligand to the ruthenium atom. Model structures of the complexes are presented based on preliminary geometry optimization procedures using the PC Spartan Pro. These possible antitumor ruthenium ascorbate complexes are highly soluble in water making them good candidates for more effective intracellular transit and possible antitumor function.
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It's been a long time since I passed by my old website then I've seen my thesis. I wonder how I was able to make this thesis. Looks greek to me!
